The impact of ambrisentan and tadalafil upfront combination therapy on cardiac function in scleroderma associated pulmonary arterial hypertension patients: cardiac magnetic resonance feature tracking study
نویسندگان
چکیده
منابع مشابه
Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension.
BACKGROUND Data on the effect of initial combination therapy with ambrisentan and tadalafil on long-term outcomes in patients with pulmonary arterial hypertension are scarce. METHODS In this event-driven, double-blind study, we randomly assigned, in a 2:1:1 ratio, participants with World Health Organization functional class II or III symptoms of pulmonary arterial hypertension who had not pre...
متن کاملCardiac magnetic resonance imaging in pulmonary arterial hypertension.
Cardiac magnetic resonance imaging (CMRI) provides accurate information about right ventricular (RV) mass, RV volumes and other markers of RV function. CMRI is proving to be a particularly useful tool in pulmonary arterial hypertension (PAH), as measures of RV function have been shown to be prognostic of long-term outcomes in this disease. Changes in RV function can also provide important infor...
متن کاملFeature Tracking in Cardiac Magnetic Resonance Imaging
Purpose: An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown that strain is a more sensitive and earlier marker for contractile dysfunction than ejection fraction (EF). Current CMR technologies for strain assessment are time consuming and difficult to implement in daily clinical practice. Feature tracking is...
متن کاملAmbrisentan therapy for pulmonary arterial hypertension.
OBJECTIVES The purpose of this study was to examine the efficacy and safety of four doses of ambrisentan, an oral endothelin type A receptor-selective antagonist, in patients with pulmonary arterial hypertension (PAH). BACKGROUND Pulmonary arterial hypertension is a life-threatening and progressive disease with limited treatment options. Endothelin is a vasoconstrictor and smooth muscle cell ...
متن کاملRole of cardiac magnetic resonance imaging in the management of patients with pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by abnormally elevated blood pressure of the pulmonary circulation that results, over time, from extensive vascular remodeling and increased pulmonary vascular resistance. Recent advances in magnetic resonance imaging (MRI) technology have led to the development of techniques for noninvasive assessment of cardiovascul...
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ژورنال
عنوان ژورنال: Pulmonary Circulation
سال: 2017
ISSN: 2045-8940,2045-8940
DOI: 10.1177/2045893217748307